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The Immune Cell Landscape in Kidneys of Lupus Nephritis Patients
Internal Dataset- Authors
- Arnon AraziDeepak A. RaoCeline BerthierAnne Davidson39 more author(s)...
- Description
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control subjects using single-cell RNA sequencing. Our analysis revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid...
- Subject
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KidneyLupus NephritisRNA-SeqSequence Analysis, RNA
- Access Rights
- Free to all with registrationApplication Required
- Local Expert
- Anne DavidsonArnon AraziBetty Diamond
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Identification of grade and origin specific cell populations in serous epithelial ovarian cancer by single cell RNA-seq
Internal Dataset- Authors
- Andrew ShihAndrew MenzinJill WhyteJohn Lovecchio5 more author(s)...
- Description
Here we investigated different cell populations within ovarian cancer using single-cell RNA seq: fourteen samples from nine patients with differing grades (high grade, low grade and benign) as well as different origin sites (primary and metastatic tumor site, ovarian in origin and fallopian in origin).
- Subject
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CancerCarcinoma, Ovarian EpithelialOvarian NeoplasmsRNA-SeqSequence Analysis, RNA
- Access Rights
- Free to All
- Local Expert
- Andrew ShihAnnette LeePeter Gregersen
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Basal cytokine secretion in human breast cancer cells and non-carcinogenic breast epithelial cells – 41-cytokine MILLIPLEX assay data
Internal Dataset- Authors
- Karin ChenLeo SatlofGuillaume StoffelsUdithi Kothapalli4 more author(s)...
- Description
Human breast cancer cells (MDA-MB-231, MCF-7, T-47D, and BT-474) and non-carcinogenic breast epithelial (MCF-10A) cells were grown for 24 and 48 hours in 1 ml of serum-free medium. Using MILIPLEX assay kit (MilliporeSigma, Cat. # HCYTOMAG-60K), we measured the levels of the following cytokines in cell culture conditioned medium: EGF, FGF-2, TGFα, PDGF-AA, PDGF-AB/BB, TNFα, TNFβ, IFN-α2, IFN-γ, CCL2,...
- Subject
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Breast CancerCancerInflammation
- Access Rights
- Free to All
- Local Expert
- Dimiter Avtanski